Mucosal Immune Development in Early Life: Setting the Stage

Immunonutrition in Early Life: Diet and Immune Development

The belief that “you are what you eat” originated from Brillat-Savarin et al. (“tell me what you eat, and I will tell you who you are”) in the 1800s [1] was the starting point in the quest to understand the role of diet in almost every function in the body and in overall health. However, prior to the 1950s, there was little recognition of the relationship between nutrition and immune function. ...

Immune System Evidence For Early Aging in the Mucosal

Setting the stage: an anatomist's view of the immune system.

Anatomical strategies that help cells to interact greatly increase the efficiency of the adaptive immune system. In vivo, antigens are presented in a complex environment, wherein their movements and those of antigenpresenting cells, T cells and B cells are subject to anatomical constraints. Specialized subcompartments appear to facilitate cell-to-cell contact and recognition and provide the mos...

Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes

Type 1 diabetes (T1D) is an immune-mediated disease with a strong genetic basis but might be influenced by non-genetic factors such as microbiome development that "programs" the immune system during early life as well. Factors influencing pathogenesis, including a leaky intestinal mucosal barrier, an aberrant gut microbiota composition, and altered immune responsiveness, offer potential targets...

Emerging immunologic biomarkers: setting the (TNM-immune) stage.

The cooperation of tumor-infiltrating lymphocytes and tertiary lymphoid tissue in early-stage colorectal carcinoma further corroborates the strong immune influences on tumor progression and patient outcome. Immune factors in the tumor microenvironment may warrant inclusion in pathology reports and staging systems for prognostication and prediction of therapeutic response.